Kev tswj cov impurities hauv cov kuab tshuaj amide yog ib qho tseem ceeb ntawm kev ua kom cov khoom zoo thiab kev ruaj khov. Cov kuab tshuaj amide feem ntau suav nrog N, N-dimethylformamide (DMF), N, N-dimethylacetamide (DMAC), thiab N-methyl-2-pyrrolidone (NMP). Thaum lub sij hawm tsim khoom, kho kom zoo, khaws cia, thiab kev thauj mus los, cov kuab tshuaj no tuaj yeem ua paug nrog cov khoom xws li cov dej noo, cov khoom seem seem, cov tshuaj acidic, lwm cov organic compounds, thiab cov kab hlau ions. Cov dej noo ntau dhau tuaj yeem cuam tshuam qhov kev ruaj ntseg ntawm qee cov tshuaj tiv thaiv, hloov cov viscosity ntawm cov tshuaj polymer, thiab cuam tshuam rau cov khoom sib xws. Lub caij no, acidic impurities thiab residual reactants tuaj yeem cuam tshuam cov tshuaj lom neeg ruaj khov ntawm cov kuab tshuaj, uas cuam tshuam rau kev ua haujlwm ntawm cov khoom kawg. Yog li ntawd, cov txheej txheem ntau lawm yuav tsum nruj me ntsis tswj-los ntawm qhov zoo ntawm cov khoom siv raw thiab cov tshuaj tiv thaiv rau cov txheej txheem refining. Qhov no suav nrog kev ua kom zoo dua qhov kub thiab txias, qhov sib piv ntawm cov khoom siv raw, thiab cov tshuaj tiv thaiv ntev kom txo qis kev cuam tshuam sab nraud thiab tsim cov impurities, nrog rau kev siv cov txheej txheem xws li fractional distillation, lub cev qhuav dej, lossis lwm yam kev ua kom huv huv kom txo qis impurity. Rau cov kuab tshuaj amide-raws li npaj rau siv hauv cov khoom siv hluav taws xob, kev ua cov polymer, lossis cov tshuaj zoo, nws tseem tsim nyog los tswj cov qib ntawm cov hlau ions, tsis muaj teeb meem tsis zoo, thiab cov organic impurities tshwj xeeb los tiv thaiv cov kab mob tsis zoo los ntawm kev cuam tshuam cov khoom lag luam. Cov kev txwv tshwj xeeb yuav tsum tau tsim raws li hom hnyav, qib khoom, thiab cov kev cai ntawm cov txheej txheem hauv qab; ib qho, cov txheej txheem tshwj xeeb tsis tuaj yeem siv rau tag nrho cov kuab tshuaj amide.
Cov txheej txheem rau kev kuaj impurity thiab batch traceability yuav tsum tau tsim rau amide-raws li cov kuab tshuaj, nrog rau kev tsom mus rau qhov tsis xws li purity, noo noo, acidity, xim, thiab lwm yam impurities. Purity feem ntau txiav txim siab siv txoj hauv kev xws li roj chromatography, thaum cov ntsiab lus noo noo ntsuas los ntawm Karl Fischer titration method. Hlau ion concentrations tuaj yeem txheeb xyuas tau siv cov tswv yim xws li inductively coupled plasma mass spectrometry (ICP-MS) lossis lwm txoj hauv kev tsim nyog analytical, nyob ntawm seb qhov kev ntsuas tshwj xeeb. Txhua qhov kev ntsuam xyuas yuav tsum tau ua los ntawm kev siv cov cuab yeej ntsuas ntsuas, ua raws li cov txheej txheem tsim los rau kev kuaj, ntsuas, thiab cov ntaub ntawv. Tsis tas li ntawd, cov ntaub ntawv tshwm sim yuav tsum tau muab piv rau cov khoom siv kev qhia tshwj xeeb thiab cov qauv zoo. Thaum lub sij hawm cia, cov kuab tshuaj yuav tsum tau khaws cia rau hauv huv si, qhuav, thiab sib xyaw ntim ntim kom tsis txhob muaj cov dej noo, lub sij hawm raug rau huab cua, lossis kev sib kis los ntawm lwm yam tshuaj. Hloov cov kav dej, lub tank cia, thiab cov khoom siv xa tawm yuav tsum tau tshuaj xyuas tsis tu ncua kom huv si kom ntseeg tau tias tsis muaj cov khoom seem hauv cov khoom. Txhua pawg nrog cov txiaj ntsig tsis zoo yuav tsum raug cais tawm tam sim; ib qho kev tshawb nrhiav zoo-npog cov khoom siv raw, cov khoom siv ntau lawm, cov txheej txheem ua kom huv, thiab cov xwm txheej khaws cia-yuav tsum tau ua los txheeb xyuas lub hauv paus ua ntej txiav txim siab seb cov khoom puas yuav tsum tau rov ua dua lossis pov tseg. Tsis tas li ntawd, raws li cov kuab tshuaj xws li DMF, DMAC, thiab NMP ua rau muaj kev pheej hmoo ntawm kev noj qab haus huv sib txawv, kev tswj hwm tsis huv yuav tsum tau ua ke nrog kev ua haujlwm kaw, kev tso pa tawm hauv zos, kev siv cov cuab yeej tiv thaiv tus kheej (PPE), thiab kev tswj xyuas cov dej khib nyiab. Qhov no ua kom cov khoom zoo, kev nyab xeeb kev ua haujlwm, thiab kev tswj hwm ib puag ncig txhua qhov ua tau raws li qhov yuav tsum tau ua.
